PT-141 · Dosing & maths
PT-141 dosage: what the research used
This page collects the doses reported in published PT-141 research and works through the reconstitution maths for common vial sizes. It does not recommend any dose.
Doses used in published research
The Vyleesi label is 1.75 mg subcutaneously, injected at least 45 minutes before anticipated sexual activity, no more than one dose in 24 hours and no more than eight doses a month.
PT-141 reconstitution table
Syringe units (U-100: 100 units = 1 mL) needed for a given amount, by vial size and water volume:
| Vial | Water | Concentration | 500 µg | 1 mg | 1.75 mg |
|---|---|---|---|---|---|
| 10 mg | 1 mL | 10 mg/mL | 5 units | 10 units | 17.5 units |
| 10 mg | 2 mL | 5 mg/mL | 10 units | 20 units | 35 units |
| 10 mg | 3 mL | 3.333 mg/mL | 15 units | 30 units | 52.5 units |
PT-141 reconstitution calculator
Arithmetic aid for laboratory reconstitution. It does not recommend any amount for any use.
Handling and storage
Reconstitute with bacteriostatic water, adding it slowly down the vial wall and swirling rather than shaking — see the reconstitution guide. Once mixed, refrigerate at 2–8 °C; unmixed lyophilised powder keeps longest frozen (storage guide). Converting between units, mL and mg is covered in syringe units explained.
PT-141 dosing FAQs
How much bacteriostatic water for a 10 mg PT-141 vial?
There is no fixed amount — the volume sets the concentration. Adding 2 mL to a 10 mg vial gives 5 mg/mL; 1 mL gives 10 mg/mL, 2 mL gives 5 mg/mL, 3 mL gives 3.333 mg/mL.
How many units is 500 µg of PT-141?
At 5 mg/mL (10 mg in 2 mL), 500 µg is 0.1 mL, or 10 units on a U-100 syringe. A different water volume changes this — use the calculator above.
Is there an approved PT-141 dose?
See the published trial doses above. Any human use of a licensed medicine should follow its prescribing information and a prescriber's advice.
What is a PT-141 dosage chart?
A table showing how many syringe units a given amount takes at a given concentration. The reconstitution table on this page is one, calculated for 10 mg vials.